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Br J Psychiatry. 2005 Oct;187:366-71.

Clinical implications of Brief Psychiatric Rating Scale scores.

Author information

  • 1Klinik fürr Psychiatrie und Psychotherapie derTechnischen Universität München, Klinikum rechts der Isar, Ismaningerstrasse 22, 81675 München, Germany. Stefan.Leucht@lrz.tu-muenchen.de

Abstract

BACKGROUND:

Despite the widespread use of the Brief Psychiatric Rating Scale (BPRS), the clinical meaning of its total score and cut-off values used to define treatment response are unclear.

AIMS:

To link the BPRS to Clinical Global Impression (CGI) ratings.

METHOD:

Equipercentile linking of BPRS and CGI ratings from seven drug trials in acutely ill patients with schizophrenia (n=1979).

RESULTS:

'Mildly ill' according to the CGI approximately corresponded to a BPRS total score of 31, 'moderately ill'to a BPRS score of 41 and'markedly ill'to a BPRS score of 53.'Minimally improved'according to the CGI score was associated with percentage BPRS reductions of 24, 27 and 30% at weeks 1, 2 and 4, respectively. The corresponding numbers for a CGI rating of 'much improved' were 44, 53 and 58%.

CONCLUSIONS:

The results provide a clearer understanding of how to interpret BPRS total and percentage reduction scores in clinical trials with patients acutely ill with schizophrenia who are experiencing positive symptoms.

PMID:
16199797
[PubMed - indexed for MEDLINE]
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