J Neurooncol. 2005 Dec;75(3):267-72.

Pediatric high-grade glioma: molecular genetic clues for innovative therapeutic approaches.

Source

Division of Hematology/Oncology, Center for Cancer and Immunology Research, Children's National Medical Center, Washington, DC 20010, USA. Brood@cnmc.org

Abstract

High grade glioma remains the most intractable childhood tumor of the central nervous system. The molecular genetics of childhood high grade glioma remain largely unknown in comparison to that of their adult counterparts. In an era of molecularly targeted therapies, this dearth of knowledge will present particular challenges to those who must design and implement the next generation of therapeutic trials with these new agents. In this review, we discuss the current understanding of the molecular genetics of childhood high grade glioma and compare/contrast it to that of the adult tumors bearing the same classification for the purpose of beginning to identify the most promising therapeutic targets.

PMID:: 16195804; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Review Incorporating molecular tools into clinical trials and treatment for gliomas? [Curr Opin Neurol. 2007]
Review Incorporating molecular tools into clinical trials and treatment for gliomas?
Lassman AB, Holland EC. Curr Opin Neurol. 2007 Dec; 20(6):708-11.
Review New treatment strategies for malignant gliomas. [Expert Rev Anticancer Ther. 2006]
Review New treatment strategies for malignant gliomas.
Sathornsumetee S, Rich JN. Expert Rev Anticancer Ther. 2006 Jul; 6(7):1087-104.
ENU administration causes genomic instability along with single nucleotide polymorphisms in p53 during gliomagenesis: T11TS administration demonstrated in vivo apoptosis of these genetically altered tumor cells. [Cancer Biol Ther. 2006]
ENU administration causes genomic instability along with single nucleotide polymorphisms in p53 during gliomagenesis: T11TS administration demonstrated in vivo apoptosis of these genetically altered tumor cells.
Mukherjee J, Ghosh A, Ghosh A, Chaudhuri S. Cancer Biol Ther. 2006 Feb; 5(2):156-64. Epub 2006 Feb 10.
Review New molecular targets and novel anticancer treatments: emerging trends in neuro-oncology. [Expert Rev Anticancer Ther. 2006]
Review New molecular targets and novel anticancer treatments: emerging trends in neuro-oncology.
Brandes AA, Franceschi E. Expert Rev Anticancer Ther. 2006 Aug; 6(8):1129-31.
Review Development of novel targeted therapies in the treatment of malignant glioma. [Nat Rev Drug Discov. 2004]
Review Development of novel targeted therapies in the treatment of malignant glioma.
Rich JN, Bigner DD. Nat Rev Drug Discov. 2004 May; 3(5):430-46.

See reviews... See all...

Cited by 4 PubMed Central articles

Mesenchymal migration as a therapeutic target in glioblastoma. [J Oncol. 2010]
Mesenchymal migration as a therapeutic target in glioblastoma.
Zhong J, Paul A, Kellie SJ, O'Neill GM. J Oncol. 2010; 2010:430142. Epub 2010 Jun 21.
Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas. [Neuro Oncol. 2010]
Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas.
Qu HQ, Jacob K, Fatet S, Ge B, Barnett D, Delattre O, Faury D, Montpetit A, Solomon L, Hauser P, et al. Neuro Oncol. 2010 Feb; 12(2):153-63. Epub 2009 Oct 15.
Pharmacokinetics of erlotinib for the treatment of high-grade glioma in a pediatric patient with cystic fibrosis: case report and review of the literature. [Pharmacotherapy. 2009]
Pharmacokinetics of erlotinib for the treatment of high-grade glioma in a pediatric patient with cystic fibrosis: case report and review of the literature.
Christiansen SR, Broniscer A, Panetta JC, Stewart CF. Pharmacotherapy. 2009 Jul; 29(7):858-66.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Pediatric high-grade glioma: molecular genetic clues for innovative therapeutic ...
Pediatric high-grade glioma: molecular genetic clues for innovative therapeutic approaches.
J Neurooncol. 2005 Dec ;75(3):267-72.

PubMed
Lipid replacement/antioxidant therapy as an adjunct supplement to reduce the adv...
Lipid replacement/antioxidant therapy as an adjunct supplement to reduce the adverse effects of cancer therapy and restore mitochondrial function.
Pathol Oncol Res. 2005 ;11(3):139-44. Epub 2005 Sep 29 .

PubMed
Drug delivery via the mucous membranes of the oral cavity.
Drug delivery via the mucous membranes of the oral cavity.
J Pharm Sci. 1992 Jan ;81(1):1-10.

PubMed
Measuring patient safety climate: a review of surveys.
Measuring patient safety climate: a review of surveys.
Qual Saf Health Care. 2005 Oct ;14(5):364-6.

PubMed
Emotion and autonomic nervous system activity in the Minangkabau of west Sumatra...
Emotion and autonomic nervous system activity in the Minangkabau of west Sumatra.
J Pers Soc Psychol. 1992 Jun ;62(6):972-88.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Pediatric high-grade glioma: molecular genetic clues for innovative therapeutic approaches.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 4 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information