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Gene Ther. 2006 Mar;13(6):496-502.

Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?

Author information

  • 1Novartis Institutes for BioMedical Research, Genome and Proteome Sciences, Basel, Switzerland. jan.weiler@novartis.com

Abstract

MicroRNAs (miRNAs) are endogenous 19-25 nucleotide RNAs that have recently emerged as a novel class of important gene-regulatory molecules involved in many critical developmental and cellular functions. miRNAs have been implicated in the pathogenesis of several human diseases, such as neurodegenerative disorders, cancer, and more recently in viral and metabolic diseases. Unraveling the roles of miRNAs in cellular processes linked to human diseases will lead to novel opportunities for the regulation of protein function and will help to evaluate their potential for therapeutic intervention. Approaches to interfere with miRNA function in vitro and in vivo based on synthetic anti-miRNA oligonucleotides (AMOs) are discussed in this review.

Gene Therapy (2006) 13, 496-502. doi:10.1038/sj.gt.3302654; published online 29 September 2005.

PMID:
16195701
[PubMed - indexed for MEDLINE]
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