Leuk Lymphoma. 2005 Oct;46(10):1513-6.

Translocation of BCL2 and BCL6 to the same immunoglobulin heavy chain locus in a case of follicular lymphoma.

Rack K, Delannoy A, Ravoet C, Vannuffel P, Hamels J, Gillerot Y.

Source

Centre de Génétique Humaine, Institut de Pathologie et de Génétique, Allée des Templiers, Loverval 6280, Belgium. katrina.rack@ipg.be

Abstract

Follicular Lymphoma is a low grade malignancy of mature B-cells. The hallmark chromosome abnormality is the translocation t(14;18) which is observed in 70 - 80% of cases with a translocation t(3;14) present in a further 10%. Rarely both of these translocations, or one of their variants, may be present. These co-incident translocations usually involve different Ig loci or different Ig alleles. We present here a case of Follicular Lymphoma with leukemic presentation and a complex translocation involving the IgH, BCL2 and BCL6 loci. Double oncogene translocations to a single immunoglobulin locus are extremely rare in lymphomas with few cases described to date. To our knowledge this is the first reported case with a complex translocation involving these loci.

PMID:: 16194898; [PubMed - indexed for MEDLINE]

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