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Mult Scler. 2005 Oct;11(5):617-21.

Neuromyelitis optica with hypothalamic involvement.

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  • 1McGill University Health Centre, The Montreal Neurological Institute and Hospital, 3801 University Street, Montreal, Quebec, Canada.


We describe two cases of neuromyelitis optica (NMO) with clinical and radiographically confirmed features of hypothalamic involvement, in the absence of other parenchymal brain lesions. Their course is otherwise typical of Devic's form of NMO. A review of the literature identifies additional cases of NMO in which clinical features attributable to under-recognized dysfunction of the hypothalamic-pituitary axis were present. We propose that the currently accepted criteria for the diagnosis of NMO could be revisited to recognize the possibility of lesions developing within hypothalamic structures.

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