Mult Scler. 2005 Oct;11(5):504-10.

Concordance for multiple sclerosis in Danish twins: an update of a nationwide study.

Hansen T, Skytthe A, Stenager E, Petersen HC, Brønnum-Hansen H, Kyvik KO.

Source

Department of Epidemiology and Biostatistics, National Institute of Public Health, Oster Farimagsgade 5, DK-1399 København K, Denmark. tha@niph.dk

Abstract

The occurrence of multiple sclerosis (MS) in twins has not previously been studied in complete nationwide data sets. The existence of almost complete MS and twin registries in Denmark ensures that essentially unbiased samples of MS cases among twins can be obtained. In this population-based study, virtually all Danish MS cases among twins born before 1983 with onset of MS after 1948 and diagnosis before I January 1997 were identified. Of 13 286 MS cases, 178 were twins and, of these 164 twin pairs were discordant and seven were concordant. We found significantly higher proband-wise concordance among monozygotic twins than dizygotic twins, with estimated proband-wise concordances of 24% (95% confidence interval (CI): 5-39%) for monozygotic and 3% (95% CI: 0-8%) for dizygotic twins. Thus, a monozygotic twin whose co-twin has MS has a 24% risk of developing the disease, while the corresponding risk for a dizygotic twin is only 3%. Our results largely confirm previously published concordance estimates and indicate that genetic factors are of importance in susceptibility to MS.

Comment in

Mult Scler. 2005 Oct;11(5):497-9.

PMID:: 16193885; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Multiple Sclerosis - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Genetic liability in stroke: a long-term follow-up study of Danish twins. [Stroke. 2002]
Genetic liability in stroke: a long-term follow-up study of Danish twins.
Bak S, Gaist D, Sindrup SH, Skytthe A, Christensen K. Stroke. 2002 Mar; 33(3):769-74.
Risk for multiple sclerosis in dizygotic and monozygotic twins. [Mult Scler. 2005]
Risk for multiple sclerosis in dizygotic and monozygotic twins.
Hansen T, Skytthe A, Stenager E, Petersen HC, Kyvik KO, Brønnum-Hansen H. Mult Scler. 2005 Oct; 11(5):500-3.
Adolescent idiopathic scoliosis in twins: a population-based survey. [Spine (Phila Pa 1976). 2007]
Adolescent idiopathic scoliosis in twins: a population-based survey.
Andersen MO, Thomsen K, Kyvik KO. Spine (Phila Pa 1976). 2007 Apr 15; 32(8):927-30.
Review Review of the contribution of twin studies in the search for non-genetic causes of multiple sclerosis. [Neuroepidemiology. 1996]
Review Review of the contribution of twin studies in the search for non-genetic causes of multiple sclerosis.
James WH. Neuroepidemiology. 1996; 15(3):132-41.
Review [Genetic aspects in multiple sclerosis: I. Twin studies]. [Arq Neuropsiquiatr. 1996]
Review [Genetic aspects in multiple sclerosis: I. Twin studies].
de Rezende PA, Arruda WO. Arq Neuropsiquiatr. 1996 Sep; 54(3):433-8.

See reviews... See all...

Cited by 8 PubMed Central articles

CCR5Δ32 Polymorphism Associated with a Slower Rate Disease Progression in a Cohort of RR-MS Sicilian Patients. [Mult Scler Int. 2011]
CCR5Δ32 Polymorphism Associated with a Slower Rate Disease Progression in a Cohort of RR-MS Sicilian Patients.
D'Angelo R, Crisafulli C, Rinaldi C, Ruggeri A, Amato A, Sidoti A. Mult Scler Int. 2011; 2011:153282. Epub 2011 Jun 23.
Review The epigenetics of autoimmunity. [Cell Mol Immunol. 2011]
Review The epigenetics of autoimmunity.
Meda F, Folci M, Baccarelli A, Selmi C. Cell Mol Immunol. 2011 May; 8(3):226-36. Epub 2011 Jan 31.
Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. [Genome Med. 2011]
Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data.
Wang JH, Pappas D, De Jager PL, Pelletier D, de Bakker PI, Kappos L, Polman CH, Australian and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene), Chibnik LB, Hafler DA, et al. Genome Med. 2011 Jan 18; 3(1):3. Epub 2011 Jan 18.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Concordance for multiple sclerosis in Danish twins: an update of a nationwide st...
Concordance for multiple sclerosis in Danish twins: an update of a nationwide study.
Mult Scler. 2005 Oct ;11(5):504-10.

PubMed
A reproductive screening test of goldenseal.
A reproductive screening test of goldenseal.
Birth Defects Res B Dev Reprod Toxicol. 2005 Oct ;74(5):399-404.

PubMed
Allelic imbalance analysis of oral tongue squamous cell carcinoma by high-densit...
Allelic imbalance analysis of oral tongue squamous cell carcinoma by high-density single nucleotide polymorphism arrays using whole-genome amplified DNA.
Hum Genet. 2005 Dec ;118(3-4):504-7. Epub 2005 Sep 29 .

PubMed
The unilateral measurement of blood pressure may mask the diagnosis or delay the...
The unilateral measurement of blood pressure may mask the diagnosis or delay the effective treatment of hypertension.
Angiology. 2005 Sep-Oct ;56(5):565-9.

PubMed
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists re...
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations.
EMBO J. 2005 Oct 19 ;24(20):3635-46. Epub 2005 Sep 29 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: