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Virchows Arch. 2005 Nov;447(5):787-93. Epub 2005 Sep 28.

Molecular pathology of well-differentiated thyroid carcinomas.

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  • 1Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), R. Roberto Frias s/n, 4200, Porto, Portugal.


The newly discovered molecular features of well-differentiated thyroid carcinomas derived from follicular cells are reviewed, within the frame of the 2004 WHO classification of thyroid tumours, under the following headings: "Follicular carcinoma", "Papillary carcinoma", "Follicular variant of papillary carcinoma" and "Hürthle cell tumours". A particular emphasis is put on the meaning of PAX8-PPARgamma rearrangements, RAS and BRAF mutations, and deletions and mutations of mitochondrial genes and of nuclear genes encoding for mitochondrial enzymes, for thyroid tumorigenesis.

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