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J Clin Pathol. 2005 Oct;58(10):1107-9.

Colonic angiomyolipoma with a monotypic expression and a predominant epithelioid component.

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  • 1Queens Medical Centre University Hospital, Nottingham NG7 2UH, UK.


Angiomyolipomas are rare lesions, often arising in the kidney, and are part of a group of tumours with a diverse appearance and evidence of dual melanocytic and smooth muscle differentiation known as PEComas (tumours of perivascular epithelioid cell origin). This report describes an unusual case of a colonic PEComa in a 40 year old woman. Unlike most of the previous colonic angiomyolipomas/PEComas reported in the literature, this case formed a large, mainly extrinsic mass and was monotypic, and composed entirely of the myomatous component with no adipose tissue or typical vasculature.

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