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1: Antimicrob Agents Chemother. 2005 Oct;49(10):4335-8.Click here to read Click here to read Links

Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis.

Johnson CM, Pandey R, Sharma S, Khuller GK, Basaraba RJ, Orme IM, Lenaerts AJ.

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, 80523-1682, USA. christine.johnson@colostate.edu

We evaluated the efficacy of nanoparticle-encapsulated antituberculosis drugs administered every 10 days versus that of daily nonencapsulated drugs against Mycobacterium tuberculosis aerosol infection in guinea pigs. Both treatments significantly reduced the bacterial count and lung histopathology, suggesting that the nanoparticle drug delivery system has potential in intermitted treatment of tuberculosis.

PMID: 16189115 [PubMed - indexed for MEDLINE]

PMCID: PMC1251542

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