Drug Deliv. 2005 Sep-Oct;12(5):261-5.

A novel method for selective delivery of drugs to the pulmonary arteries.

Source

Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA. mark.p.yeager@hitchcock.org

Abstract

Drug treatment of pulmonary hypertension may be limited by systemic hypotension. Selective action of a vasodilator drug in pulmonary arteries could be achieved by administering a vasodilator gas into systemic venous blood so that it dilates pulmonary arteries before immediate first-pass elimination via exhalation. This article presents in vivo data to show that a pharmacologically active gas can be delivered safely into systemic venous blood where it has a distribution pattern and physiologic effects similar to those observed when the gas is inhaled into pulmonary venous (systemic arterial) blood. This is a first step toward development of first-pass pulmonary clearance as a mechanism to concentrate drugs in pulmonary arteries.

PMID:: 16188724; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

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Halothane

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2-BROMO-2-CHLORO-1,1,1-TRIFLUOROETHANE - HSDB

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