Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Genet Dev. 2005 Dec;15(6):584-8. Epub 2005 Sep 26.

Common themes in the genome strategies of pathogens.

Author information

  • 1Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.

Abstract

Genomes of pathogenic bacteria evolve by large-scale changes in gene inventory. The continual acquisition of genomic islands, which refines their metabolic arsenal, is offset by gene loss. Far from this being a passive deletion of genes no longer useful to pathogens, the removal of genes encoding problematic metabolic process and immunogenic surface antigens might be strongly beneficial. Genomes of virulent eukaryotes show the footprint of similar genomic alterations, including acquisition of genes by lateral transfer, and genome degradation in obligate pathogens. These common features suggest that unicellular pathogens share common strategies for adaptation.

PMID:
16188434
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk