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Org Biomol Chem. 2005 Aug 21;3(16):2930-4. Epub 2005 Jul 7.

Efficient terpene hydroxylation catalysts based upon P450 enzymes derived from actinomycetes.

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  • 1School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JJ, UK.


The hydroxylation of alpha-ionone 1 and beta-ionone 2 to their corresponding mono-hydroxylated derivatives has been examined using a recombinant E. coli whole cell system, in which cytochromes P450 SU1 and SU2, and P450 SOY were over-expressed with their cognate ferrodoxins. Both substrates are hydroxylated with a high degree of regioselectivity and for alpha-ionone 1 the reaction is highly diastereoselective yielding the anti-isomer.

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