Abstract
The authors quantified amyloid and tau tangles in Religious Orders Study participants. In separate analyses, amyloid and tangles were related to level of cognition. When terms for education's interaction with amyloid and tangles were added, education dampened the association of amyloid with level of cognition (p = 0.02) but not the association of neurofibrillary tangles with level of cognition, suggesting that education is related to factors that reduce the effect of amyloid on cognition.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Activities of Daily Living
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Age of Onset
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Aged
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Aged, 80 and over
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Alzheimer Disease / diagnosis
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Alzheimer Disease / pathology*
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Alzheimer Disease / prevention & control
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Cerebral Cortex / pathology*
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Cerebral Cortex / physiopathology
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Cognition / physiology
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Cognition Disorders / diagnosis
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Cognition Disorders / pathology*
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Cognition Disorders / prevention & control
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Disease Progression
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Educational Status
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Female
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Humans
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Life Style
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Male
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Nerve Tissue Proteins / biosynthesis
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Neural Pathways / metabolism
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Neural Pathways / pathology
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Neural Pathways / physiopathology
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Neurofibrillary Tangles / pathology*
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Neurons / metabolism
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Neurons / pathology
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Plaque, Amyloid / pathology*
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tau Proteins
Substances
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MAPT protein, human
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Nerve Tissue Proteins
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tau Proteins