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Neurology. 2005 Sep 27;65(6):928-30.

Increasing incidence of late-onset anti-AChR antibody-seropositive myasthenia gravis.

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  • 1Department of Autoimmunology, Statens Serum Institut, DK-2300 Copenhagen S, Denmark.


The incidence of myasthenia gravis (MG) from 1970 through 1999 was studied in an area with 2.3 million inhabitants. The mean annual incidence rate of early-onset MG was constant at 3.5 x 10(-6). In late-onset MG, the rate increased from 4.7 to 20.8 x 10(-6). The two onset types of MG may thus be distinct disorders. The author hypothesized that late-onset nonthymoma anti-acetylcholine receptor antibody-seropositive MG may be provoked by environmental factors.

[PubMed - indexed for MEDLINE]
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