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Diabetes Care. 2005 Oct;28(10):2501-7.

Smoking and incidence of diabetes among U.S. adults: findings from the Insulin Resistance Atherosclerosis Study.

Author information

  • 1Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. cfoy@wfubmc.edu

Abstract

OBJECTIVE:

The objective of this study was to determine the association between smoking and incident diabetes among U.S. adults.

RESEARCH DESIGN AND METHODS:

The Insulin Resistance Atherosclerosis Study (IRAS) was a prospective study of the associations of insulin sensitivity and cardiovascular risk factors. We examined the relationship between smoking status categories (never, former, and current) and incident 5-year type 2 diabetes among 906 participants free of diabetes at baseline. We also considered the effect of pack-year categories (never, former <20 pack-years, former > or = 20 pack-years, current <20 pack-years, and current > or = 20 pack-years) upon diabetes incidence.

RESULTS:

Of current smokers, 96 (25%) developed diabetes at 5 years, compared with 60 (14%) never smokers. After multivariable adjustment, current smokers exhibited increased incidence of diabetes compared with never smokers (odds ratio [OR] 2.66, P = 0.001). Similar results were found among current smokers with > or = 20 pack-years with normal glucose tolerance (5.66, P = 0.001).

CONCLUSIONS:

Smoking shares a robust association with incident diabetes, supporting the current Surgeon General's warnings against cigarette smoking.

PMID:
16186287
[PubMed - indexed for MEDLINE]
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