Bioorg Med Chem Lett. 2005 Dec 1;15(23):5182-6. Epub 2005 Sep 23.

Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390.

Barboni L, Ballini R, Giarlo G, Appendino G, Fontana G, Bombardelli E.

Source

Dipartimento di Scienze Chimiche, Università di Camerino, Via S. Agostino 1, 62032 Camerino (MC), Italy. luciano.barboni@unicam.it

Abstract

Starting from 10-deacetylbaccatin III (7), the 2-debenzoyl-2-m-methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized. The biological evaluation of these compounds (5 and 6, respectively) showed a general increase of cytotoxicity, as observed in first-generation anticancer taxanes.

PMID:: 16183281; [PubMed - indexed for MEDLINE]

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