Exp Neurol. 1992 Jul;117(1):94-6.

Amitriptyline produces analgesia in the formalin pain test.

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Department of Psychology, McGill University, Montreal, Quebec, Canada.

Abstract

A dose of 20 mg/kg of amitriptyline reduced pain in the second phase of the formalin test, which is an animal model of long-lasting pain in humans. Since the analgesic effect was produced by a single dose, which is insufficient to produce an antidepressant effect, these results indicate that amitriptyline has analgesic properties that are independent of its antidepressant properties.

PMID:: 1618291; [PubMed - indexed for MEDLINE]

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Amitriptyline produces analgesia in the formalin pain test.

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