J Am Soc Mass Spectrom. 2005 Nov;16(11):1781-6. Epub 2005 Sep 22.

Detection and quantification of 3,5,3'-triiodothyronine and 3,3',5'-triiodothyronine by electrospray ionization tandem mass spectrometry.

Source

Division of Biology, Kansas State University, Ackert Hall, Manhattan, KS 66506-4901, USA. ytz@ksu.edu

Abstract

A novel and rapid method for identifying and quantifying 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3; reverse T3) has been introduced using electrospray ionization tandem mass spectrometry (ESI-MS/MS). MS(2) spectra in either negative ionization mode or positive ionization mode can be used to differentiate T3 and rT3. Quantification of the T3 and rT3 isomers under the negative ionization mode is also achieved without prior separation by HPLC.

PMID:: 16182556; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, N.I.H., Extramural

MeSH Terms

Substances

Triiodothyronine

Grant Support

EY 000952/EY/NEI NIH HHS/United States

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LIOTHYRONINE - HSDB

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