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Nat Rev Cancer. 2005 Oct;5(10):786-95.

The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.

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  • 1Department of General and Environmental Physiology, University of Bari, Via Amendola 165/A, 70126 Bari, Italy.

Abstract

Recent research has highlighted the fundamental role of the tumour's extracellular metabolic microenvironment in malignant invasion. This microenvironment is acidified primarily by the tumour-cell Na(+)/H(+) exchanger NHE1 and the H(+)/lactate cotransporter, which are activated in cancer cells. NHE1 also regulates formation of invadopodia - cell structures that mediate tumour cell migration and invasion. How do these alterations of the metabolic microenvironment and cell invasiveness contribute to tumour formation and progression?

PMID:
16175178
[PubMed - indexed for MEDLINE]
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