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Nat Rev Microbiol. 2005 Nov;3(11):859-69.

Discovering novel biology by in silico archaeology.

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  • 1Laboratory of Microbiology, Wageningen University, 6703 CT Wageningen, The Netherlands.


Archaea are prokaryotes that evolved in parallel with bacteria. Since the discovery of the distinct status of the Archaea, extensive physiological and biochemical research has been conducted to elucidate the molecular basis of their remarkable lifestyle and their unique biology. Here, we discuss how in-depth comparative genomics has been used to improve the annotation of archaeal genomes. Combined with experimental verification, bioinformatic analysis contributes to the ongoing discovery of novel metabolic conversions and control mechanisms, and as such to a better understanding of the intriguing biology of the Archaea.

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