Brain Res Bull. 1992 May;28(5):821-3.

Immobility-reducing effects of antidepressants in a genetic animal model of depression.

Schiller GD, Pucilowski O, Wienicke C, Overstreet DH.

Source

School of Biological Sciences, Flinders University of South Australia, Adelaide.

Abstract

Chronic treatment with the tricyclic antidepressants imipramine (15 mg/kg) and desmethylimipramine (5 mg/kg) significantly reduced the exaggerated immobility normally exhibited by the Flinders Sensitive Line (FSL) rats in the Forced Swim Test. The control group, Flinders Resistant Line (FRL) rats were only slightly affected. In contrast, chronic treatment with the anticholinesterase diisopropyl fluorophosphate at doses known to down regulate muscarinic receptors did not alter swim test immobility in either FSL or FRL rats. Our findings support the validity of the FSL rats as an animal model of depression and suggest that serotonergic and/or noradrenergic, but not cholinergic mechanisms, may underlie the exaggerated immobility of the FSL rats.

PMID:: 1617465; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Review Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression. [Psychopharmacology (Berl). 1995]
Review Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression.
Overstreet DH, Pucilowski O, Rezvani AH, Janowsky DS. Psychopharmacology (Berl). 1995 Sep; 121(1):27-37.
Effects of melatonin receptor ligands on swim test immobility. [Neuroreport. 1998]
Effects of melatonin receptor ligands on swim test immobility.
Overstreet DH, Pucilowski O, Retton MC, Delagrange P, Guardiola-Lemaitre B. Neuroreport. 1998 Jan 26; 9(2):249-53.
Review The Flinders sensitive line rats: a genetic animal model of depression. [Neurosci Biobehav Rev. 1993]
Review The Flinders sensitive line rats: a genetic animal model of depression.
Overstreet DH. Neurosci Biobehav Rev. 1993 Spring; 17(1):51-68.
Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. [Pharmacol Biochem Behav. 2010]
Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression.
Overstreet DH, Naimoli VM, Griebel G. Pharmacol Biochem Behav. 2010 Aug; 96(2):206-10. Epub 2010 May 12.
Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression. [Psychopharmacology (Berl). 2004]
Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression.
Overstreet DH, Hlavka J, Feighner JP, Nicolau G, Freed JS. Psychopharmacology (Berl). 2004 Sep; 175(3):303-9.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Immobility-reducing effects of antidepressants in a genetic animal model of depr...
Immobility-reducing effects of antidepressants in a genetic animal model of depression.
Brain Res Bull. 1992 May ;28(5):821-3.

PubMed
Systemic lupus erythematosus and the extended major histocompatibility complex--...
Systemic lupus erythematosus and the extended major histocompatibility complex--evidence for several predisposing loci.
Rheumatology (Oxford). 2005 Nov ;44(11):1368-73. Epub 2005 Sep 20 .

PubMed
Genetic susceptibility to type 2 diabetic nephropathy in human and animal models...
Genetic susceptibility to type 2 diabetic nephropathy in human and animal models.
Nephrology (Carlton). 2005 Oct ;10 Suppl:S22-5.

PubMed
Chronic lithium administration alters a prominent PKC substrate in rat hippocamp...
Chronic lithium administration alters a prominent PKC substrate in rat hippocampus.
Brain Res. 1992 Jan 20 ;570(1-2):333-40.

PubMed
CA125 in ovarian cancer: European Group on Tumor Markers guidelines for clinical...
CA125 in ovarian cancer: European Group on Tumor Markers guidelines for clinical use.
Int J Gynecol Cancer. 2005 Sep-Oct ;15(5):679-91.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: