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    J Am Chem Soc. 2005 Sep 28;127(38):13164-6.

    A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling.

    Lee J, Zylka MJ, Anderson DJ, Burdette JE, Woodruff TK, Meade TJ.

    Department of Chemistry, Northwestern University, Evanston, Illinois 60201, USA.

    We have synthesized the first steroid hormone-MR contrast agent conjugate designed to track the cell signaling process upon binding to a gene switch system. The derivative has a high relaxivity and when tested in vitro is active as a progesterone antagonist (RU-486). By combining a transcriptional system and a noninvasive imaging technology, such as MRI, it would be a powerful tool to research the cell signaling pathway in vivo.

    PMID: 16173742 [PubMed - indexed for MEDLINE]

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