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J Infect Dis. 2005 Oct 15;192(8):1398-406. Epub 2005 Sep 14.

A randomized study of serial telephone call support to increase adherence and thereby improve virologic outcome in persons initiating antiretroviral therapy.

Author information

  • 1University of Washington School of Medicine and Harborview Medical Center, Seattle, WA 98104, USA. acollier@u.washington.edu

Abstract

BACKGROUND:

Adherence to antiretroviral therapy is difficult, and methods to increase it are needed.

METHODS:

We tested the impact of supportive telephone calls in an adherence substudy of a treatment trial. Subjects initiating antiretroviral therapy received either each site's usual adherence support measures or usual support measures and scripted serial telephone calls (16 calls during 96 weeks).

RESULTS:

A total of 282 subjects enrolled: 140 in the usual support measures group and 142 in the calls group. A total of 75% of expected calls were completed. Virologic failure occurred in 97 (34%) subjects: 52 (37%) of those in the usual support measures group and 45 (32%) of those in the calls group; time to virologic failure was not different (P=.32). In each group, >72% of subjects reported > or =95% adherence, with no difference between groups. Independent predictors of higher rates of virologic failure were <95% adherence, receiving the 4-drug regimen with nelfinavir, and female sex; older age was associated with decreased likelihood of virologic failure. Receiving the 4-drug regimen with nelfinavir, higher stress scores, older age, and higher call completion rates were independently associated with higher adherence.

CONCLUSIONS:

Serial telephone calls did not improve virologic outcome but had an impact on self-reported adherence.

PMID:
16170757
[PubMed - indexed for MEDLINE]
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