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Bioorg Med Chem. 2006 Jan 1;14(1):33-40. Epub 2005 Sep 19.

Beta-cyclodextrin derivatives that inhibit anthrax lethal toxin.

Author information

  • 1Innovative Biologics, Inc., 10900 University Blvd., Manassas, VA 20110, USA. vak@innovbio.com

Abstract

Recently, we demonstrated that simultaneous blocking of bacterial growth by antibiotics and inhibition of anthrax toxin action with antibodies against protective antigen were beneficial for the treatment of anthrax. The present study examined the hypothesis that blocking the pore formed by protective antigen can inhibit the action of anthrax toxin. The potential inhibitors were chosen by a structure-based design using beta-cyclodextrin as the starting molecule. Several beta-cyclodextrin derivatives were evaluated for their ability to protect RAW 264.7 cells from the action of anthrax lethal toxin. Per-substituted aminoalkyl derivatives displayed inhibitory activity and were protective against anthrax lethal toxin action at low micromolar concentrations. These results provide the basis for a structure-based drug discovery program, with the goal of identifying new drug candidates for anthrax treatment.

PMID:
16169738
[PubMed - indexed for MEDLINE]
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