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C R Biol. 2005 Sep;328(9):773-82. Epub 2005 Apr 20.

Yeast mediator and its role in transcriptional regulation.

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  • 1Department of Biochemistry, University of Washington, Box 357350, Seattle, WA 98195-7350, USA.


Activated eukaryotic transcription requires the components of the Mediator complex, which can act as both a positive and negative regulator of transcription. This review of the yeast Saccharomyces cerevisiae Mediator complex describes the role of Mediator and its effects on transcriptional regulation. One focal point of the review is to summarize new information regarding the negative effect of Mediator on transcription and suggest a possible mechanism that encompasses the latest results.

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