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Bioessays. 2005 Oct;27(10):995-8.

Synaptonemal complex formation: where does it start?

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  • 1Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.


The synaptonemal complex is a prominent, evolutionarily conserved feature of meiotic prophase. The assembly of this structure is closely linked to meiotic recombination. A recent study in budding yeast reveals an unexpected role in centromere pairing for a protein component of the synaptonemal complex, Zip1. These findings have implications for synaptonemal complex formation.

(c) 2005 Wiley Periodicals, Inc.

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