Int J Hematol. 2005 Jun;81(5):378-84.

GATA transcription factors in hematologic disease.

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Division of Pediatric Hematology/Oncology, Children's Hospital Boston, Boston, Massachusetts 02115, USA. alan.cantor@childrens.harvard.edu

Abstract

GATA family transcription factors play essential roles in broad developmental settings. GATA-1, one of the hematopoietically expressed members, is required for normal erythroid and megakaryocytic differentiation. Over the past few years, mutations in the gene encoding GATA-1 have been linked to several human hematologic disorders, including X-linked dyserythropoietic anemia and thrombocytopenia, X-linked thrombocytopenia and beta-thalassemia, and Down syndrome acute megakaryoblastic leukemia. This review summarizes the role of GATA-1 during normal hematopoiesis and discusses how disease-associated mutations may affect its function.

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GATA transcription factors in hematologic disease.
GATA transcription factors in hematologic disease.
Int J Hematol. 2005 Jun ;81(5):378-84.

PubMed
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Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome.
Nat Genet. 2002 Sep ;32(1):148-52. Epub 2002 Aug 12 .

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GATA transcription factors in hematologic disease.

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