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Neuron. 2005 Sep 15;47(6):779-82.

The Elegance of the MicroRNAs: A Neuronal Perspective.

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  • 1Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, California 93106, USA. kosik@lifesci.ucsb.edu


As knowledge of microRNAs (miRNA) grows from a compendium of sequences to annotated functional data it has become increasingly clear that a highly significant segment of regulatory biology depends on these approximately 22 nucleotide noncoding transcripts. The expression of many miRNAs in the nervous system, some with a high degree of temporal and spatial specificity, suggests that understanding miRNAs in the nervous system will yield rewarding neurobiological insights. High on the list of insights that microRNAs promise is a deeper understanding of the remarkable cellular diversity found among neurons. This review examines the interface between an emerging biology of miRNAs and their role in nervous systems.

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