Metagenomics-based drug discovery and marine micro...[Trends Biotechnol. 2005]

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1: Trends Biotechnol. 2005 Nov;23(11):539-43. Epub 2005 Sep 12. Links

Metagenomics-based drug discovery and marine microbial diversity.

Li X, Qin L.

South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, China 510301. lixiang@scsio.ac.cn

As the global threat of drug-resistant pathogens continues to rise, new strategies and resources are required to accelerate and advance the drug discovery process. We believe that rapid progress in metagenomics has opened up a new era in the study of marine microbial diversity that enables direct access to the genomes of numerous uncultivable microorganisms. This review outlines recent developments and future trends in metagenomics-based drug discovery in marine microbial communities and their associated chemical prosperity.

PMID: 16154653 [PubMed - indexed for MEDLINE]

[Marine microbial metagenomics: progress and prospect] [Wei Sheng Wu Xue Bao. 2007]
ReviewMicrobial ecology in the age of genomics and metagenomics: concepts, tools, and recent advances. [Mol Ecol. 2006]
Review[Development of antituberculous drugs: current status and future prospects] [Kekkaku. 2006]
ReviewBiodiversity, chemical diversity and drug discovery. [Prog Drug Res. 2008]
ReviewMetagenomics: application of genomics to uncultured microorganisms. [Microbiol Mol Biol Rev. 2004]

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Metagenomics-based drug discovery and marine microbial diversity.

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