Send to:

Choose Destination
See comment in PubMed Commons below
Pflugers Arch. 1992 Apr;420(5-6):618-20.

A method for exceptionally low noise single channel recordings.

Author information

  • 1Department of Physiology and Biophysics, Mayo Foundation, Rochester, MN 55905.


We present a method whereby, with integrating electronics, quartz patch electrodes and a novel use of silicone oil, background noise levels as low as .083 pA RMS in a 5 kHz bandwidth (4-pole Butterworth filter) have been achieved in single channel patch clamp recordings. These approaches result in much higher signal to noise ratios for single channel recording than have previously been reported and should allow many investigators to significantly reduce noise at a constant bandwidth or to increase their recording bandwidths by several kHz.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk