Bioorg Med Chem. 2005 Dec 1;13(23):6470-6. Epub 2005 Sep 6.

Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells.

Kolodziej H, Burmeister A, Trun W, Radtke OA, Kiderlen AF, Ito H, Hatano T, Yoshida T, Foo LY.

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Institute of Pharmacy, Pharmaceutical Biology, Freie Universität Berlin, Germany. kolpharm@zedat.fu-berlin.de

Abstract

Some polyphenol-containing extracts (Pelargonium sidoides, Phyllanthus amarus) and representatives of simple phenols (shikimic acid 3- and 5-O-gallate), flavan-3-ols (epigallocatechin 3-gallate), proanthocyanidins (a hexamer) and hydrolysable tannins (corilagin, casuariin, geraniin) were studied for gene expressions (iNOS, IL-1, IL-10, IL-12, IL-18, TNF-alpha, IFN-alpha/gamma) by RT-PCR. All extracts and compounds were capable of enhancing the iNOS and cytokine mRNA levels in parasitised cells when compared with those in non-infected conditions.

PMID:: 16143535; [PubMed - indexed for MEDLINE]

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Tannins and related compounds induce nitric oxide synthase and cytokines gene ex...
Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells.
Bioorg Med Chem. 2005 Dec 1 ;13(23):6470-6. Epub 2005 Sep 6 .

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