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Nat Struct Mol Biol. 2005 Sep;12(9):742-6.

Actin and myosin I in the nucleus: what next?

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  • 1the Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois 60612, USA. primal@uic.edu


Several recent publications have demonstrated the importance of nuclear actin and nuclear myosin I in transcription. Here we review these publications and their implications. In addition, we discuss some important issues that should be addressed to gain a more comprehensive understanding of how these traditionally 'cytoplasmic' proteins are involved in transcription. We propose highly speculative models and mechanisms solely to stimulate thought and experimentation in this area.

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