Science. 2005 Sep 2;309(5740):1529-30.

Fewer genes, more noncoding RNA.

Source

Structural and Genomics Information Laboratory, CNRS UPR 2589, Institut de Biologie Structurale et Microbiologie, 31 chemin Joseph Aiguier, Marseille 13402, France. jean-michel.claverie@igs.cnrs-mrs.fr

Abstract

Recent studies showing that most "messenger" RNAs do not encode proteins finally explain the long-standing discrepancy between the small number of protein-coding genes found in vertebrate genomes and the much larger and ever-increasing number of polyadenylated transcripts identified by tag-sampling or microarray-based methods. Exploring the role and diversity of these numerous noncoding RNAs now constitutes a main challenge in transcription research.

PMID:: 16141064; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription. [Genome Biol. 2007]
Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription.
Nakaya HI, Amaral PP, Louro R, Lopes A, Fachel AA, Moreira YB, El-Jundi TA, da Silva AM, Reis EM, Verjovski-Almeida S. Genome Biol. 2007; 8(3):R43.
Review Differentiating protein-coding and noncoding RNA: challenges and ambiguities. [PLoS Comput Biol. 2008]
Review Differentiating protein-coding and noncoding RNA: challenges and ambiguities.
Dinger ME, Pang KC, Mercer TR, Mattick JS. PLoS Comput Biol. 2008 Nov; 4(11):e1000176. Epub 2008 Nov 28.
Comparative analysis of genome tiling array data reveals many novel primate-specific functional RNAs in human. [BMC Evol Biol. 2007]
Comparative analysis of genome tiling array data reveals many novel primate-specific functional RNAs in human.
Zhang Z, Pang AW, Gerstein M. BMC Evol Biol. 2007 Feb 8; 7 Suppl 1:S14. Epub 2007 Feb 8.
Review Computational genomics of noncoding RNA genes. [Cell. 2002]
Review Computational genomics of noncoding RNA genes.
Eddy SR. Cell. 2002 Apr 19; 109(2):137-40.
Mapping of conserved RNA secondary structures predicts thousands of functional noncoding RNAs in the human genome. [Nat Biotechnol. 2005]
Mapping of conserved RNA secondary structures predicts thousands of functional noncoding RNAs in the human genome.
Washietl S, Hofacker IL, Lukasser M, Hüttenhofer A, Stadler PF. Nat Biotechnol. 2005 Nov; 23(11):1383-90.

See reviews... See all...

Cited by 31 PubMed Central articles

Whole transcriptome RNA-Seq analysis of breast cancer recurrence risk using formalin-fixed paraffin-embedded tumor tissue. [PLoS One. 2012]
Whole transcriptome RNA-Seq analysis of breast cancer recurrence risk using formalin-fixed paraffin-embedded tumor tissue.
Sinicropi D, Qu K, Collin F, Crager M, Liu ML, Pelham RJ, Pho M, Rossi AD, Jeong J, Scott A, et al. PLoS One. 2012; 7(7):e40092. Epub 2012 Jul 13.
BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration. [Genome Res. 2012]
BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration.
Flockhart RJ, Webster DE, Qu K, Mascarenhas N, Kovalski J, Kretz M, Khavari PA. Genome Res. 2012 Jun; 22(6):1006-14. Epub 2012 May 11.
microPIR: an integrated database of microRNA target sites within human promoter sequences. [PLoS One. 2012]
microPIR: an integrated database of microRNA target sites within human promoter sequences.
Piriyapongsa J, Bootchai C, Ngamphiw C, Tongsima S. PLoS One. 2012; 7(3):e33888. Epub 2012 Mar 16.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Fewer genes, more noncoding RNA.
Fewer genes, more noncoding RNA.
Science. 2005 Sep 2 ;309(5740):1529-30.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: