Trends Microbiol. 2005 Oct;13(10):497-503.

A mouse model for S. typhimurium-induced enterocolitis.

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Institute of Microbiology, ETH Hönggerberg, Wolfgang-Pauli-Str. 10, 8093 Zürich, Switzerland.

Abstract

Salmonella typhimurium has emerged as a model pathogen that manipulates host cells in a complex fashion, thus causing disease. In humans, S. typhimurium causes acute intestinal inflammation. Intriguingly, type III secreted virulence proteins have a central role in this process. At the cellular level, the functions of these factors are well characterized; at present, animal models are required for elucidating how these factors trigger inflammatory disease in vivo. Calf infection models have been employed successfully and, recently, a mouse model was identified: in streptomycin-pretreated mice, S. typhimurium causes acute colitis. This mouse model provides a new avenue for research into acute intestinal inflammation because it enables the manipulation and dissection of both the bacterial and host contributions to the disease in unsurpassed detail.

PMID:: 16140013; [PubMed - indexed for MEDLINE]

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