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J Hepatol. 2005 Dec;43(6):990-6. Epub 2005 Jul 5.

A meta-analysis of transjugular intrahepatic portosystemic shunt versus paracentesis for refractory ascites.

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  • 1Servicio de Gastroenterología, Hospital Universitario Ramón y Cajal, Departamento de Medicina, Universidad de Alcalá, Madrid, Spain. aalbillosm@meditex.es

Abstract

BACKGROUND/AIMS:

Meta-analysis designed to provide evidence-based guidance on the effect of TIPS and paracentesis on mortality and encephalopathy in cirrhotic patients with refractory ascites.

METHODS:

Five randomized trials published between 1989 and 2005 were identified.

RESULTS:

The five trials involved 330 patients, and none included patients >76 years, with bilirubin >5-10 mg/dl or creatinine >3 mg/dl. Ascites recurrence was lower in the TIPS arm (RR 0.56; 95% CI 0.47-0.66). TIPS was associated with a greater risk of encephalopathy (RR 1.36; 95% CI 1.1-1.68) and severe encephalopathy (RR 1.72; 95% CI 1.14-2.58). TIPS did not affect mortality, as estimated by the RR (0.93; 95% CI 0.67-1.28, random effect model) and pooled hazard ratio (RR 1.09; 95% CI 0.84-1.88). Analysis of this outcome measure was limited by significant heterogeneity among trials. Liver-related mortality was homogenous and similar in both arms. Results were unaffected by excluding trials of lower quality or with a greater number of alcoholics. Meta-analysis of trials including patients with recidivant ascites revealed a lower mortality in the TIPS arm (RR 0.68; 95% CI 0.49-0.93).

CONCLUSIONS:

In patients with refractory ascites, a better control of ascites by TIPS does not translate into improved survival and worsens encephalopathy.

Comment in

PMID:
16139922
[PubMed - indexed for MEDLINE]
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