FEBS Lett. 2005 Sep 12;579(22):5084-8.

p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells.

Herrera B, Carracedo A, Diez-Zaera M, Guzmán M, Velasco G.

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Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, c/José Antonio Novais s/n, 28040 Madrid, Spain.

Abstract

Cannabinoids have been shown to inhibit the growth of a broad spectrum of tumour cells. However, the molecular mechanisms involved in that effect have not been completely elucidated. Here, we investigated the possible involvement of mitogen-activated protein kinases (MAPKs) in CB2 receptor-induced apoptosis of human leukaemia cells. Results show that stimulation of the CB2 receptor leads to p38 MAPK activation and that inhibition of this kinase attenuates CB2 receptor-induced caspase activation and apoptosis. These findings support a role for p38 MAPK in CB2 receptor-induced apoptosis of human leukaemia cells.

PMID:: 16139274; [PubMed - indexed for MEDLINE]

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