Format

Send to:

Choose Destination
See comment in PubMed Commons below
Dev Cell. 2005 Sep;9(3):377-88.

Syndecan recycling [corrected] is controlled by syntenin-PIP2 interaction and Arf6.

Author information

  • 1Laboratory for Glycobiology and Developmental Genetics, Department of Human Genetics, University of Leuven, Belgium. pascale.zimmerman@med.kuleuven.be

Erratum in

  • Dev Cell. 2005 Nov;9(5):721.

Abstract

Syndecans are heparan sulfate proteoglycans that modulate the activity of several growth factors and cell adhesion molecules. PDZ domains in the adaptor protein syntenin interact with syndecans and with the phosphoinositide PIP(2), which is involved in the regulation of the actin cytoskeleton and membrane trafficking. Here, we show that the syntenin PDZ domain-PIP(2) interaction controls Arf6-mediated syndecan recycling through endosomal compartments. FGF receptor accompanies syndecan along the syntenin-mediated recycling pathway, in a heparan sulfate- and FGF-dependent manner. Syndecans that cannot recycle via this pathway become trapped intracellularly and inhibit cell spreading. This syntenin-mediated syndecan recycling pathway may regulate the surface availability of a number of cell adhesion and signaling molecules.

PMID:
16139226
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk