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Curr Biol. 2005 Sep 6;15(17):R651-3.

Microtubule motors: LSD2 trips the toggle.

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  • 1Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, USA.


The Perilipin homologue LSD2 has been identified as a regulator of microtubule motor activity in Drosophila embryos. LSD2 is required for the net directional transport of lipid droplets and the new data support a model in which the protein imparts bias onto a molecular toggle that otherwise randomly engages minus and plus end motors in a paired set.

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