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Clin Calcium. 2005 Sep;15(9):1489-94.

[Vitamin D, K and bone mineral density].

[Article in Japanese]

Author information

  • 1Department of Hygienic Sciences, Kobe Pharmaceutical University.

Abstract

Both vitamin D and vitamin K are essential nutrients for bone health. It is believed that vitamin D deficiency is responsible for rickets in infants and osteomalacia in adults, and chronic vitamin D insufficiency induces hyperparathyroidism and reduces bone mineral density, resulting in an increased risk of osteoporosis. Vitamin K deficiency is thought to cause impaired activation of bone matrix protein osteocalcin, and reduction of osteoblast function, resulting in impaired bone formation. Recently, we reported that a high prevalence of low vitamin D status (low serum 25-hydroxyvitamin D concentration) . low bone mineral density, and a high prevalence of low vitamin K status (high serum undercarboxylated osteocalcin concentration) . high frequency of bone fracture in elderly women in Japan. However, no correlation between low vitamin K status and low bone mineral density was observed in this subjects.

PMID:
16137948
[PubMed - indexed for MEDLINE]
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