Bioorg Med Chem Lett. 2005 Oct 15;15(20):4427-31.

Design and synthesis of phthalimide-type histone deacetylase inhibitors.

Shinji C, Nakamura T, Maeda S, Yoshida M, Hashimoto Y, Miyachi H.

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Institute of Molecular and Cellular Biosciences, The University of Tokyo Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

Abstract

Several hydroxamic acid derivatives with a substituted phthalimide group as a linker and/or cap structure, prepared during structural development studies based on thalidomide, were found to have histone deacetylase (HDAC)-inhibitory activity. Structure-activity relationship studies indicated that nature of the substituent introduced at the phthalimide nitrogen atom, introduction of a hydroxamic acid structure, and distance between the N-hydroxyl group and the cap structure are important for HDAC-inhibitory activity.

PMID:: 16137884; [PubMed - indexed for MEDLINE]

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Cited by 1 PubMed Central article

Anti-tumor effect in human lung cancer by a combination treatment of novel histone deacetylase inhibitors: SL142 or SL325 and retinoic acids. [PLoS One. 2010]
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