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Eur J Obstet Gynecol Reprod Biol. 2006 Apr 1;125(2):211-6. Epub 2005 Aug 30.

Obstetric outcome of 6346 pregnancies with infants affected by congenital heart defects.

Author information

  • 1Division of Obstetrics and Gynaecology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. marie.cedergren@lio.se

Abstract

OBJECTIVE:

To evaluate whether pregnancies with infants affected by congenital heart defects are associated with adverse obstetric and perinatal outcome.

STUDY DESIGN:

In a prospective population-based cohort study from Sweden (1992-2001), 6346 singleton pregnancies with infants affected by congenital heart defects were, after suitable adjustments, compared to all delivered women.

RESULTS:

The prevalence of cardiovascular defects was 9.1 per 1000 births. Among them, mothers of 6346 infants (71%) had information on maternal smoking habits and maternal height and weight in early pregnancy that enabled the calculation of BMI. All cases with known chromosomal abnormalities and/or maternal pre-existing diabetes were excluded. Eighty-four percent (n=5338) had an isolated cardiovascular defect. Severe types occurred in 21.7% (n=1378). In the group of pregnancies with infants affected by congenital heart defects as compared to all delivered women, there was an increased risk of the following outcomes (adjusted OR (95%CI)): pre-eclampsia (1.21 (1.06-1.37)), cesarean section (1.91 (1.79-2.03)), instrumental delivery (1.21 (1.10-1.34)), pre-term delivery (2.58 (2.39-2.79)), small-for gestational age (1.96 (1.77-2.16)), meconium aspiration (1.51 (1.28-1.77)), and fetal distress (1.38 (1.17-1.63)).

CONCLUSIONS:

Pregnancies with infants affected by congenital heart defects are associated with several obstetric and neonatal complications.

PMID:
16137818
[PubMed - indexed for MEDLINE]
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