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1: J Rheumatol. 1992 May;19(5):807-9.Links

Fever, hepatitis and acute interstitial nephritis in a patient with rheumatoid arthritis. Concurrent manifestations of azathioprine hypersensitivity.

Meys E, Devogelaer JP, Geubel A, Rahier J, Nagant de Deuxchaisnes C.

Department of Rheumatology, Louvain University, St-Luc University Hospital, Brussels, Belgium.

We describe a patient with rheumatoid arthritis (RA) who developed hypersensitivity after 3 weeks of therapy with azathioprine with fever, jaundice and renal insufficiency. A percutaneous liver biopsy was compatible with hypersensitivity hepatitis. During azathioprine rechallenge, the symptoms recurred within a few days, consistent with the diagnosis of an acute hypersensitivity reaction. This report is the first to describe the association of an azathioprine induced hypersensitivity simultaneously involving the liver and the kidneys, in the same patient with RA, with resurgence after rechallenge.

PMID: 1613715 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Mercaptopurine (Purinethol® )

    Your doctor has ordered the drug mercaptopurine to help treat your illness. The drug is taken by mouth in tablet form.

  • Azathioprine (Azasan® , Imuran® )

    Azathioprine is used with other medications to prevent rejection of kidney transplants. It is also used to treat severe rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain and swellin...

  • Source: AHFS Consumer Medication Information