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Nat Rev Genet. 2005 Aug;6(8):654-62.

Molecular clocks: four decades of evolution.

Author information

  • Center for Evolutionary Functional Genomics, The Biodesign Institute and School of Life Sciences, Arizona State University, Tempe 85287-5301, USA. s.kumar@asu.edu

Abstract

During the past four decades, the molecular-clock hypothesis has provided an invaluable tool for building evolutionary timescales, and has served as a null model for testing evolutionary and mutation rates in different species. Molecular clocks have also influenced the development of theories of molecular evolution. As DNA-sequencing technologies have progressed, the use of molecular clocks has increased, with a profound effect on our understanding of the temporal diversification of species and genomes.

PMID:
16136655
[PubMed - indexed for MEDLINE]
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