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Nature. 2005 Sep 1;437(7055):45-6.

Phytochemistry: ibuprofen-like activity in extra-virgin olive oil.

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  • 1Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA.

Abstract

Newly pressed extra-virgin olive oil contains oleocanthal--a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen. We show here that this similar perception seems to be an indicator of a shared pharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen. Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.

PMID:
16136122
[PubMed - indexed for MEDLINE]
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