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    Nature. 2005 Sep 1;437(7055):45-6.

    Phytochemistry: ibuprofen-like activity in extra-virgin olive oil.

    Beauchamp GK, Keast RS, Morel D, Lin J, Pika J, Han Q, Lee CH, Smith AB, Breslin PA.

    Source

    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA.

    Abstract

    Newly pressed extra-virgin olive oil contains oleocanthal--a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen. We show here that this similar perception seems to be an indicator of a shared pharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen. Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.

    PMID:
    16136122
    [PubMed - indexed for MEDLINE]

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