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J Alzheimers Dis. 2005 Aug;7(4):331-53.

Genes involved in Alzheimer's disease, a survey of possible candidates.

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  • 1Department of Psychiatry, Vita-Salute University School of Medicine, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy.


Alzheimer's disease (AD) is the major cause of dementia in the elderly. It is characterized by a progressive deterioration in memory and cognitive functions, but also behavioral symptoms are common. Many different genes are possibly involved in Alzheimer's Disease: four genetic factors were confirmed in different studies, while at least 50 additional genes were tested with contrasting results. A major aim both for clinician and researchers would be the identification of the genes involved in AD, to better understand the biological mechanism of this disease and consequently to develop appropriate treatments. The aim of this review is to explore genetics of AD.

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