[Prevalence of thrombophilia in patients with severe ovarian hyperstimulation syndrome]

Ceska Gynekol. 2005 Jul;70(4):254-7.
[Article in Czech]

Abstract

Objective: To determine the prevalence of markers of thrombophilia in patients with severe form of ovarian hyperstimulation syndrome

Design: Retrospective case - control study

Setting: Unica, Institute for Reproductive Medicine, Brno

Methods: Blood samples to test for markers of thrombophilia were obtained from 30 patients who were hospitalised for severe OHSS. Results were compared with two control groups.

Results: None of the patients with severe OHSS had antithrombin, protein C or protein S deficiencies. We also did not observe increased prothrombin level. Six patients had factor V Leiden mutation (heterozygotes) which is statistically significant compared to control group (p = 0.01, OR 4.65) and 12 patients had mutation of MTHFR 677 (heterozygotes). None had prothrombin G20210A mutation.

Conclusion: We found a statistically significant increase in the prevalence of factor V Leiden mutation (heterozygot) in Czech infertile women with severe OHSS. These findings suggest the increased risk of development of OHSS in these patients.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Factor V / genetics
  • Female
  • Humans
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics
  • Mutation
  • Ovarian Hyperstimulation Syndrome / blood*
  • Pregnancy
  • Thrombophilia / complications*
  • Thrombophilia / diagnosis
  • Thrombophilia / genetics

Substances

  • factor V Leiden
  • Factor V
  • Methylenetetrahydrofolate Reductase (NADPH2)