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    Science. 2005 Aug 26;309(5739):1373-6.

    Spatial coordination of spindle assembly by chromosome-mediated signaling gradients.

    Caudron M, Bunt G, Bastiaens P, Karsenti E.

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    Cell Biology and Biophysics Department, European Molecular Biology Laboratory (EMBL), EMBL, 69117 Heidelberg, Germany.

    Abstract

    During cell division, chromosomes are distributed to daughter cells by the mitotic spindle. This system requires spatial cues to reproducibly self-organize. We report that such cues are provided by chromosome-mediated interaction gradients between the small guanosine triphosphatase (GTPase) Ran and importin-beta. This produces activity gradients that determine the spatial distribution of microtubule nucleation and stabilization around chromosomes and that are essential for the self-organization of microtubules into a bipolar spindle.

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    PMID:
    16123300
    [PubMed - indexed for MEDLINE]

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