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1: J Org Chem. 2005 Sep 2;70(18):7426-8.Click here to read Links

Synthesis of heavily substituted 1,2-amino alcohols in enantiomerically pure form.

García-Delgado N, Reddy KS, Solà L, Riera A, Pericàs MA, Verdaguer X.

Unitat de Recreca en Síntesi Asimètrica (URSA-PCB), Parc Científic de Barcelona and Departament de Química Orgànica, Universitat de Barcelona, c/Josep Samitier, 1-5, E-08028 Barcelona, Spain.

[reaction: see text] A simple and convenient methodology for the preparation of optically pure 2-amino-2-aryl-1,1-diphenylethanols is presented. Allylamine was found to produce the ring-opening of triaryloxiranes in a regioselective and a stereospecific fashion. Removal of the allyl protecting group provided the free 1,2-amino alcohols in enantiomerically pure form.

PMID: 16122269 [PubMed]

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