Send to

Choose Destination
See comment in PubMed Commons below
Mitochondrion. 2004 Jul;4(2-3):223-33.

Mitochondrial membrane permeabilization by HIV-1 Vpr.

Author information

  • 1CNRS FRE 2445, Universit√© de Versailles/St Quentin, 45, avenue des Etats-Unis, 78035 Versailles, France.


The mitochondrion is a privileged target for apoptosis-modulatory proteins of viral origin. Thus, viral protein R (Vpr) can target mitochondria and induce apoptosis via a specific interaction with the permeability transition pore complex (PTPC). Vpr cooperates with the adenine nucleotide translocator (ANT) to form large conductance channels and to trigger all the hallmarks of mitochondrial membrane permeabilization (MMP). The Vpr/ANT interaction is direct, since it is abolished by the addition of a peptide corresponding to the Vpr binding site of ANT, ADP, ATP, or by Bcl-2. Accordingly, Vpr modulates MMP through direct structural and functional interactions with PTPC proteins.

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk