The postantibiotic suppressive effect of L-ofloxacin, an optically active isomer of ofloxacin

Diagn Microbiol Infect Dis. 1992 May-Jun;15(4):375-8. doi: 10.1016/0732-8893(92)90028-r.

Abstract

The postantibiotic suppressive effect (PAE) of L-ofloxacin was studied and compared with those of ciprofloxacin and norfloxacin. The PAE of L-ofloxacin was observed against all Gram-positive organisms tested: Staphylococcus aureus, S. epidermidis, and Enterococcus faecalis. At the achievable serum concentrations L-ofloxacin showed a longer PAE than ciprofloxacin and norfloxacin. Exposure of organisms to 4 micrograms/ml of L-ofloxacin for 2 hr produced a 3.1 and 4.2 hr PAE for methicillin-sensitive and methicillin-resistant staphylococci, respectively. Against E. faecalis and S. epidermidis, the PAEs of L-ofloxacin were 1.9 and 1.6 hr, respectively.

Publication types

  • Comparative Study

MeSH terms

  • Ciprofloxacin / pharmacology
  • Enterococcus faecalis / growth & development
  • Gram-Positive Cocci / drug effects*
  • Gram-Positive Cocci / growth & development*
  • Norfloxacin / pharmacology
  • Ofloxacin / pharmacology*
  • Staphylococcus aureus / growth & development
  • Staphylococcus epidermidis / growth & development
  • Stereoisomerism

Substances

  • Ciprofloxacin
  • Ofloxacin
  • Norfloxacin